Urinary porphyrin profiles as a biomarker of mercury exposure: studies on dentists with occupational exposure to mercury vapor.
Identifieur interne : 000615 ( Main/Exploration ); précédent : 000614; suivant : 000616Urinary porphyrin profiles as a biomarker of mercury exposure: studies on dentists with occupational exposure to mercury vapor.
Auteurs : J S Woods [États-Unis] ; M D Martin ; C A Naleway ; D. EcheverriaSource :
- Journal of toxicology and environmental health [ 0098-4108 ]
Descripteurs français
- KwdFr :
- Animaux (MeSH), Chromatographie en phase liquide à haute performance (MeSH), Dentistes (MeSH), Exposition professionnelle (MeSH), Humains (MeSH), Hème (biosynthèse), Marqueurs biologiques (MeSH), Mercure (effets indésirables), Mercure (urine), Mâle (MeSH), Porphyrines (urine), Rats (MeSH), Rats de lignée F344 (MeSH), Volatilisation (MeSH), États-Unis (MeSH).
- MESH :
- biosynthèse : Hème.
- effets indésirables : Mercure.
- urine : Mercure, Porphyrines.
- Animaux, Chromatographie en phase liquide à haute performance, Dentistes, Exposition professionnelle, Humains, Marqueurs biologiques, Mâle, Rats, Rats de lignée F344, Volatilisation, États-Unis.
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Animals (MeSH), Biomarkers (MeSH), Chromatography, High Pressure Liquid (MeSH), Dentists (MeSH), Heme (biosynthesis), Humans (MeSH), Male (MeSH), Mercury (adverse effects), Mercury (urine), Occupational Exposure (MeSH), Porphyrins (urine), Rats (MeSH), Rats, Inbred F344 (MeSH), United States (MeSH), Volatilization (MeSH).
- MESH :
- chemical , adverse effects : Mercury.
- chemical , biosynthesis : Heme.
- chemical , urine : Mercury, Porphyrins.
- chemical : Biomarkers.
- geographic : United States.
- Animals, Chromatography, High Pressure Liquid, Dentists, Humans, Male, Occupational Exposure, Rats, Rats, Inbred F344, Volatilization.
Abstract
Porphyrins are formed as intermediates in the biosynthesis of heme. In humans and other mammals, porphyrins with eight, seven, six, five, and four carboxyl groups are excreted in the urine in a well-established pattern. Mercury selectively alters porphyrin metabolism in kidney proximal tubule cells, leading to an altered urinary porphyrin excretion pattern. Previous studies in rats have shown that changes in the urinary porphyrin profile during exposure to mercury as methylmercury hydroxide are uniquely characterized by highly elevated (20- to 30-fold) levels of four- and five-carboxyl porphyrins and by the excretion of an atypical porphyrin ("precoproporphyrin"), which elutes on high performance liquid chromatography (HPLC) approximately midway between penta- and coproporphyrins. Changes in the urinary porphyrin profile are highly correlated with the dose and duration of mercury exposure and persist for up to 20 wk following cessation of mercury treatment. In the present studies, the utility of urinary porphyrin profile changes as a biomarker of mercury exposure in human subjects was evaluated. Urinary porphyrin concentrations were measured in dentists participating in the Health Screening Programs conducted during the 1991 and 1992 annual meetings of the American Dental Association and compared with urinary mercury levels measured in the same subjects. Among dentists with no detectable urinary mercury, mean concentrations of urinary porphyrins were within the established normal ranges for male human subjects. In contrast, among dentists with urinary mercury in excess of 20 micrograms/L, mean urinary concentrations of four- and five-carboxyl porphyrins as well as of precoproporphyrin were elevated three to four times those of unexposed subjects. Significant differences in urinary porphyrin concentrations remained when porphyrin concentrations in spot urine samples were adjusted for creatinine levels. These findings suggest that urinary porphyrin profiles may serve as a useful biomarker of mercury exposure in clinical or epidemiologic studies of mercury-related human health risks.
DOI: 10.1080/15287399309531791
PubMed: 8230299
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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In humans and other mammals, porphyrins with eight, seven, six, five, and four carboxyl groups are excreted in the urine in a well-established pattern. Mercury selectively alters porphyrin metabolism in kidney proximal tubule cells, leading to an altered urinary porphyrin excretion pattern. Previous studies in rats have shown that changes in the urinary porphyrin profile during exposure to mercury as methylmercury hydroxide are uniquely characterized by highly elevated (20- to 30-fold) levels of four- and five-carboxyl porphyrins and by the excretion of an atypical porphyrin ("precoproporphyrin"), which elutes on high performance liquid chromatography (HPLC) approximately midway between penta- and coproporphyrins. Changes in the urinary porphyrin profile are highly correlated with the dose and duration of mercury exposure and persist for up to 20 wk following cessation of mercury treatment. In the present studies, the utility of urinary porphyrin profile changes as a biomarker of mercury exposure in human subjects was evaluated. Urinary porphyrin concentrations were measured in dentists participating in the Health Screening Programs conducted during the 1991 and 1992 annual meetings of the American Dental Association and compared with urinary mercury levels measured in the same subjects. Among dentists with no detectable urinary mercury, mean concentrations of urinary porphyrins were within the established normal ranges for male human subjects. In contrast, among dentists with urinary mercury in excess of 20 micrograms/L, mean urinary concentrations of four- and five-carboxyl porphyrins as well as of precoproporphyrin were elevated three to four times those of unexposed subjects. Significant differences in urinary porphyrin concentrations remained when porphyrin concentrations in spot urine samples were adjusted for creatinine levels. These findings suggest that urinary porphyrin profiles may serve as a useful biomarker of mercury exposure in clinical or epidemiologic studies of mercury-related human health risks.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8230299</PMID><DateCompleted><Year>1993</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0098-4108</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>2-3</Issue><PubDate><MedlineDate>1993 Oct-Nov</MedlineDate></PubDate></JournalIssue><Title>Journal of toxicology and environmental health</Title><ISOAbbreviation>J Toxicol Environ Health</ISOAbbreviation></Journal><ArticleTitle>Urinary porphyrin profiles as a biomarker of mercury exposure: studies on dentists with occupational exposure to mercury vapor.</ArticleTitle><Pagination><MedlinePgn>235-46</MedlinePgn></Pagination><Abstract><AbstractText>Porphyrins are formed as intermediates in the biosynthesis of heme. 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In the present studies, the utility of urinary porphyrin profile changes as a biomarker of mercury exposure in human subjects was evaluated. Urinary porphyrin concentrations were measured in dentists participating in the Health Screening Programs conducted during the 1991 and 1992 annual meetings of the American Dental Association and compared with urinary mercury levels measured in the same subjects. Among dentists with no detectable urinary mercury, mean concentrations of urinary porphyrins were within the established normal ranges for male human subjects. In contrast, among dentists with urinary mercury in excess of 20 micrograms/L, mean urinary concentrations of four- and five-carboxyl porphyrins as well as of precoproporphyrin were elevated three to four times those of unexposed subjects. Significant differences in urinary porphyrin concentrations remained when porphyrin concentrations in spot urine samples were adjusted for creatinine levels. These findings suggest that urinary porphyrin profiles may serve as a useful biomarker of mercury exposure in clinical or epidemiologic studies of mercury-related human health risks.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Woods</LastName><ForeName>J S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Environmental Health, School of Public Health and Community Medicine, University of Washington, Seattle.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>M D</ForeName><Initials>MD</Initials></Author><Author ValidYN="Y"><LastName>Naleway</LastName><ForeName>C A</ForeName><Initials>CA</Initials></Author><Author ValidYN="Y"><LastName>Echeverria</LastName><ForeName>D</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DE00161</GrantID><Acronym>DE</Acronym><Agency>NIDCR NIH HHS</Agency><Country>United 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UI="D014481" MajorTopicYN="N" Type="Geographic">United States</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014835" MajorTopicYN="N">Volatilization</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8230299</ArticleId><ArticleId IdType="doi">10.1080/15287399309531791</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Washington (État)</li></region><settlement><li>Seattle</li></settlement><orgName><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Echeverria, D" sort="Echeverria, D" uniqKey="Echeverria D" first="D" last="Echeverria">D. Echeverria</name><name sortKey="Martin, M D" sort="Martin, M D" uniqKey="Martin M" first="M D" last="Martin">M D Martin</name><name sortKey="Naleway, C A" sort="Naleway, C A" uniqKey="Naleway C" first="C A" last="Naleway">C A Naleway</name></noCountry><country name="États-Unis"><region name="Washington (État)"><name sortKey="Woods, J S" sort="Woods, J S" uniqKey="Woods J" first="J S" last="Woods">J S Woods</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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